Drug Information

Drug General Information
Drug ID
D0Q8NO
Former ID
DIB021202
Drug Name
VUF 8328
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538760]
Formula
C7H12N4S
InChI
InChI=1S/C7H12N4S/c8-7(9)12-3-1-2-6-4-10-5-11-6/h4-5H,1-3H2,(H3,8,9)(H,10,11)
InChIKey
QJUVWGBVEFRHCN-UHFFFAOYSA-N
PubChem Compound ID
10176414
PubChem Substance ID
15171398, 24443430, 40265995, 47434796, 48105129, 49846726, 78828582, 103184401, 135651313, 163139369
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [526200]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 538760(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1246).
Ref 526200Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. J Pharmacol Exp Ther. 2001 Dec;299(3):908-14.

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