Drug Information

Drug General Information
Drug ID
D0Q8LU
Former ID
DNC009955
Drug Name
2-(1,4'-bipiperidin-1'-yl)thiazolo[4,5-c]pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530397]
Formula
C16H22N4S
Canonical SMILES
C1CCN(CC1)C2CCN(CC2)C3=NC4=C(S3)C=CN=C4
InChI
1S/C16H22N4S/c1-2-8-19(9-3-1)13-5-10-20(11-6-13)16-18-14-12-17-7-4-15(14)21-16/h4,7,12-13H,1-3,5-6,8-11H2
InChIKey
CYASDRJNADLAFT-UHFFFAOYSA-N
PubChem Compound ID
45482781
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [530397]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530397Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. Epub 2009 Sep 6.Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.
Ref 530397Bioorg Med Chem Lett. 2009 Nov 1;19(21):6176-80. Epub 2009 Sep 6.Synthesis and structure-activity relationships of 2-(1,4'-bipiperidin-1'-yl)thiazolopyridine as H3 receptor antagonists.

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