Drug Information

Drug General Information
Drug ID
D0Q8BS
Former ID
DIB018109
Drug Name
(S)-alpha-methylhistamine
Synonyms
(S)-alpha-MeHA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538751]
Formula
C6H11N3
InChI
InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
InChIKey
XNQIOISZPFVUFG-YFKPBYRVSA-N
PubChem Compound ID
6603865
PubChem Substance ID
11111248, 11113573, 26751778, 43223657, 48253918, 48253919, 49846719, 76714568, 103173271, 114636994, 129714815, 131342546, 132621871, 135650426, 139636700, 143178381, 177749645, 229974311, 247986865
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [526445]
Histamine H4 receptor Target Info Agonist [525968]
KEGG Pathway Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP1825:GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 538751(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1238).
Ref 525968Cloning and characterization of a novel human histamine receptor. J Pharmacol Exp Ther. 2001 Mar;296(3):1058-66.
Ref 526445Characteristics of recombinantly expressed rat and human histamine H3 receptors. Eur J Pharmacol. 2002 Oct 18;453(1):33-41.

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