Drug Information

Drug General Information
Drug ID
D0Q4DP
Former ID
DIB020171
Drug Name
L-750,667
Synonyms
Lopac-L-133; L750667; L-750667
Drug Type
Small molecular drug
Indication Discovery agent Investigative [543341]
Formula
C18H19IN4
InChI
InChI=1S/C18H19IN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)
InChIKey
OOEUHRGMLFVKQO-UHFFFAOYSA-N
PubChem Compound ID
6603897
PubChem Substance ID
11111361, 11646400, 15329238, 26755694, 43223689, 47275551, 48094541, 48243367, 50111123, 57370989, 75183096, 85222502, 85788368, 90341040, 99381487, 103247488, 103947635, 114637023, 124749943, 124880513, 124880514, 124880515, 128837447, 135650488, 142282998, 143160217, 179235898, 203086701, 225029774, 231053082, 251963123
Target and Pathway
Target(s) D(4) dopamine receptor Target Info Antagonist [525665]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, Other
References
Ref 543341(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 978).
Ref 525665Nonconserved residues in the second transmembrane-spanning domain of the D(4) dopamine receptor are molecular determinants of D(4)-selective pharmacology. Mol Pharmacol. 2000 Jan;57(1):144-52.

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