Drug Information

Drug General Information
Drug ID
D0Q3WC
Former ID
DNC006470
Drug Name
1-methoxy-3-(3-(pyridin-4-yl)-1H-indol-6-yl)urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528041]
Formula
C15H14N4O2
Canonical SMILES
CONC(=O)NC1=CC2=C(C=C1)C(=CN2)C3=CC=NC=C3
InChI
1S/C15H14N4O2/c1-21-19-15(20)18-11-2-3-12-13(9-17-14(12)8-11)10-4-6-16-7-5-10/h2-9,17H,1H3,(H2,18,19,20)
InChIKey
XYNMCCVGHHUPIU-UHFFFAOYSA-N
PubChem Compound ID
44410473
Target and Pathway
Target(s) Inosine-5'-monophosphate dehydrogenase 2 Target Info Inhibitor [528041]
BioCyc Pathway Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Guanosine nucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Guanosine ribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Drug metabolism - other enzymes
Metabolic pathways
PANTHER Pathway De novo purine biosynthesis
Reactome Purine ribonucleoside monophosphate biosynthesis
References
Ref 528041Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.
Ref 528041Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42. Epub 2006 Feb 17.Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships.

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