Drug Information

Drug General Information
Drug ID
D0Q3GV
Former ID
DPR000103
Drug Name
S32504
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Preclinical [526972]
Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Terminated [547082]
Company
Shionogi
Formula
C16H22N2O2
Canonical SMILES
CCCN1CCOC2C1CCC3=C2C=C(C=C3)C(=O)N
InChI
1S/C16H22N2O2/c1-2-7-18-8-9-20-15-13-10-12(16(17)19)4-3-11(13)5-6-14(15)18/h3-4,10,14-15H,2,5-9H2,1H3,(H2,17,19)/t14-,15-/m1/s1
InChIKey
XKTRZPQOQOCNJU-HUUCEWRRSA-N
CAS Number
CAS 220932-72-9
PubChem Compound ID
15389743
PubChem Substance ID
50075365, 56486681, 85244533, 103652045, 129703044, 134339543, 136352522, 229813034
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Modulator [526972]
D(2) dopamine receptor Target Info Modulator [526972]
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 526972S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole. J Pharmacol Exp Ther. 2004 Jun;309(3):921-35. Epub 2004 Feb 20.
Ref 547082Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012906)
Ref 526972S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole. J Pharmacol Exp Ther. 2004 Jun;309(3):921-35. Epub 2004 Feb 20.

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