Drug Information

Drug General Information
Drug ID
D0Q2RP
Former ID
DIB018534
Drug Name
24(S), 25-epoxycholesterol
Synonyms
24,25-epoxy-cholesterol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539796]
Formula
C27H44O2
InChI
InChI=1S/C27H44O2/c1-17(6-11-24-25(2,3)29-24)21-9-10-22-20-8-7-18-16-19(28)12-14-26(18,4)23(20)13-15-27(21,22)5/h7,17,19-24,28H,6,8-16H2,1-5H3/t17-,19+,20+,21-,22+,23+,24+,26+,27-/m1/s1
InChIKey
OSENKJZWYQXHBN-XVYZBDJZSA-N
PubChem Compound ID
3247059
PubChem Substance ID
4266373, 7886694, 10766020, 16834834, 17396622, 34612078, 47515044, 49688239, 53788894, 57356109, 76666124, 103430437, 111872634, 126684446, 135651390, 137108242, 138613671, 139600488, 177749016, 179317067, 223681223, 227189145, 248895378, 252149719
Target and Pathway
Target(s) Oxysterols receptor LXR-beta Target Info Agonist [532179]
Oxysterols receptor LXR-alpha Target Info Agonist [532179]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptorrxr_vdr_pathway:RXR and RAR heterodimerization with other nuclear receptor
Reactome Nuclear Receptor transcription pathway
WikiPathways SREBP signalling
Nuclear ReceptorsWP299:Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 539796(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2751).
Ref 532179Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Nat Chem Biol. 2013 Feb;9(2):126-33.

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