Drug Information

Drug General Information
Drug ID
D0PT1K
Former ID
DNC010731
Drug Name
2-(4-Chlorophenyl)-2H-indazole-7-carboxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530485]
Formula
C14H10ClN3O
Canonical SMILES
C1=CC2=CN(N=C2C(=C1)C(=O)N)C3=CC=C(C=C3)Cl
InChI
1S/C14H10ClN3O/c15-10-4-6-11(7-5-10)18-8-9-2-1-3-12(14(16)19)13(9)17-18/h1-8H,(H2,16,19)
InChIKey
ZUUTWXXAMVQOFT-UHFFFAOYSA-N
PubChem Compound ID
44549375
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [530485]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 530485J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Ref 530485J Med Chem. 2009 Nov 26;52(22):7170-85.Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

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