Drug Information

Drug General Information
Drug ID
D0PD1W
Former ID
DIB014639
Drug Name
Prostaglandin D2 antagonists
Synonyms
Laropiprant backup compounds, Merck & Co; Prostaglandin D2 antagonists, Merck & Co
Indication Allergic rhinitis [ICD9: 472.0, 477, 995.3; ICD10:J00, J30, J31.0, T78.4] Investigative [528672]
Company
Merck & Co Inc
Canonical SMILES
c1(cc(c2c(c1)c1c(n2[C@H](c2ccc(cc2)C(F)(F)F)C)[C@H](CCC<br />1)CC(=O)O)S(=O)(=O)C)F
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Antagonist [543775]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 528672J Med Chem. 2007 Feb 22;50(4):794-806.Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Ref 543775(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 338).

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