Drug Information

Drug General Information
Drug ID
D0P5UE
Former ID
DIB004469
Drug Name
50-235
Synonyms
Myriceric acid A
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [545617]
Company
Shionogi & Co Ltd
Canonical SMILES
[C@@]12([C@]3([C@@H]([C@@]4([C@@H](CC3)C(C(=O)CC4)(C)C)<br />C)CC=C1[C@H]1[C@@](CC2)(CCC(C1)(C)C)C(=O)O)C)COC(=O)/C=<br />C/c1cc(c(cc1)O)O
CAS Number
CAS 142877-49-4
Target and Pathway
Target(s) Endothelin-1 receptor Target Info Modulator [533968]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin secretion
Pathways in cancer
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Endothelin signaling pathway
Pathway Interaction Database Endothelins
EGFR-dependent Endothelin signaling events
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 545617Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003913)
Ref 533968Structure-activity relationships of an endothelin ETA receptor antagonist, 50-235, and its derivatives. Eur J Pharmacol. 1993 Oct 15;247(2):219-21.

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