Drug Information

Drug General Information
Drug ID
D0P5QW
Former ID
DIB020397
Drug Name
MQ1
Synonyms
MQ-1; compound (R)-10a
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532720]
Formula
C27H31N3O2
InChI
InChI=1S/C27H31N3O2/c1-18-25(29-27(31)21-7-10-24(11-8-21)32-17-20-5-6-20)12-9-22-15-23(16-28-26(18)22)19(2)30-13-3-4-14-30/h7-12,15-16,19-20H,3-6,13-14,17H2,1-2H3,(H,29,31)/t19-/m1/s1
InChIKey
DFWKNBVJNXPUBW-LJQANCHMSA-N
PubChem Compound ID
57521365
PubChem Substance ID
137278849, 160701613, 160867535, 252166788
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Modulator (allosteric modulator) [532720]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 532720The MCH(1) receptor, an anti-obesity target, is allosterically inhibited by 8-methylquinoline derivatives possessing subnanomolar binding and long residence times. Br J Pharmacol. 2014 Mar;171(5):1287-98.
Ref 532720The MCH(1) receptor, an anti-obesity target, is allosterically inhibited by 8-methylquinoline derivatives possessing subnanomolar binding and long residence times. Br J Pharmacol. 2014 Mar;171(5):1287-98.

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