Drug Information

Drug General Information
Drug ID
D0P3IZ
Former ID
DIB007231
Drug Name
E-2040
Indication Schizophrenia [ICD9: 295; ICD10:F20] Terminated [546598]
Company
Eisai Co Ltd
Canonical SMILES
c1(c(c(cc(N2CCN(CC2)CCO)c1)[C@H](F)CC)Cl)c1c(C#N)cccc1.<br />Cl
CAS Number
CAS 172732-21-7
Target and Pathway
Target(s) 5-HT 2 receptor Target Info Modulator [546599]
D(3) dopamine receptor Target Info Modulator [546599]
D(2) dopamine receptor Target Info Modulator [546599]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
References
Ref 546598Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126)
Ref 546599Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009126)

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