Drug Information

Drug General Information
Drug ID
D0P3CF
Former ID
DIB016536
Drug Name
AZD-4407
Synonyms
ZD-4407
Indication Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] Discontinued in Phase 1 [546713]
Company
AstraZeneca plc
Canonical SMILES
N1(C(=O)Cc2c1ccc(Sc1cc([C@@]3(C[C@@H](OCC3)C)O)cs1)c2)C
CAS Number
CAS 166882-70-8
Target and Pathway
Target(s) Arachidonate 5-lipoxygenase Target Info Inhibitor [532630]
BioCyc Pathway Aspirin-triggered lipoxin biosynthesis
Resolvin D biosynthesis
Leukotriene biosynthesis
Lipoxin biosynthesis
Aspirin triggered resolvin D biosynthesis
Aspirin triggered resolvin E biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Serotonergic synapse
Ovarian steroidogenesis
Toxoplasmosis
NetPath Pathway IL4 Signaling Pathway
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Vitamin D Receptor Pathway
Arachidonic acid metabolism
Eicosanoid Synthesis
Selenium Micronutrient Network
References
Ref 546713Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009803)
Ref 532630Palladium catalyzed aryl(alkyl)thiolation of unactivated arenes. Org Lett. 2014 Feb 7;16(3):848-51.

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