Drug Information

Drug General Information
Drug ID
D0P2UM
Former ID
DNC009711
Drug Name
2-(ethoxycarbonyl)-1H-indole-5-carboxylic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530151]
Formula
C12H11NO4
Canonical SMILES
CCOC(=O)C1=CC2=C(N1)C=CC(=C2)C(=O)O
InChI
1S/C12H11NO4/c1-2-17-12(16)10-6-8-5-7(11(14)15)3-4-9(8)13-10/h3-6,13H,2H2,1H3,(H,14,15)
InChIKey
CAVYPAYXEMVXMS-UHFFFAOYSA-N
PubChem Compound ID
18071365
Target and Pathway
Target(s) Histamine H3 receptor Target Info Inhibitor [530151]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 530151J Med Chem. 2009 Jul 9;52(13):3855-68.5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
Ref 530151J Med Chem. 2009 Jul 9;52(13):3855-68.5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

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