Drug Information

Drug General Information
Drug ID
D0P2HX
Former ID
DIB020862
Drug Name
RS-25344
Synonyms
RS 25344
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541681]
Formula
C19H13N5O4
InChI
InChI=1S/C19H13N5O4/c25-18-16-5-2-8-21-17(16)23(14-3-1-4-15(11-14)24(27)28)19(26)22(18)12-13-6-9-20-10-7-13/h1-11H,12H2
InChIKey
YLHRMVRLIOIWTO-UHFFFAOYSA-N
PubChem Compound ID
9842556
PubChem Substance ID
14804264, 24140471, 44940630, 79524730, 87235801, 87235805, 104248261, 129812118, 135277187, 140137086, 162403075, 162795896, 163342534, 170482541, 170482542, 172919483, 178103171, 224967492, 228577646, 252216235
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [534698]
Type IV phosphodiesterase Target Info Inhibitor [534698]
CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [534698]
PDE4C Target Info Inhibitor [534698]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathwayWP35:G Protein Signaling Pathways
References
Ref 541681(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6557).
Ref 534698Comparison of recombinant human PDE4 isoforms: interaction with substrate and inhibitors. Cell Signal. 1998 Jun;10(6):427-40.

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