TTD | Drug: D0P0QG

Drug General Information
Drug ID	D0P0QG
Former ID	DIB015152
Drug Name	HuMV833
Synonyms	Anti-VEGF antibody, Toagosei; MAb (cancer), Toagosei; SMART anti-VEGF MAb, Protein Design Labs; SMART anti-VEGF, Toagosei/PDL
Drug Type	Antibody
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Discontinued in Phase 1	[547036]
Company	Toagosei Co Ltd
Target and Pathway
Target(s)	VEGF receptor	Target Info		[526435]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Focal adhesion
	Transcriptional misregulation in cancer
	Rheumatoid arthritis
References
Ref 547036	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012394)
Ref 526435	Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies. J Natl Cancer Inst. 2002 Oct 2;94(19):1484-93.

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Drug Information