Drug Information

Drug General Information
Drug ID
D0OW9L
Former ID
DNCL001963
Drug Name
MK-3134
Indication Dementia [ICD9: 290-294; ICD10:F01-F07] Phase 1 [522645]
Company
Merck
Target and Pathway
Target(s) Histamine H3 receptor Target Info Agonist [531503]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 522645ClinicalTrials.gov (NCT00887601) BOLD Functional Magnetic Resonance Imaging (fMRI) and Cerebral Blood Flow Measurements as Biomarkers for Cognition Enhancing Drugs (3134-006). U.S. National Institutes of Health.
Ref 531503Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans. Psychopharmacology (Berl). 2011 Dec;218(3):513-24.

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