Drug Information

Drug General Information
Drug ID
D0OW2O
Former ID
DNC004379
Drug Name
U-92032
Drug Type
Small molecular drug
Indication Discovery agent Terminated [545700]
Formula
C30H35F2N3O2
Canonical SMILES
CC(C)C1=CC=C(C(=O)C(=C1)NCCO)CN2CCN(CC2)C(C3=CC=C(C=C3)<br />F)C4=CC=C(C=C4)F
InChI
1S/C30H35F2N3O2/c1-21(2)24-3-4-25(30(37)28(19-24)33-13-18-36)20-34-14-16-35(17-15-34)29(22-5-9-26(31)10-6-22)23-7-11-27(32)12-8-23/h3-12,19,21,29,36H,13-18,20H2,1-2H3,(H,33,37)
InChIKey
UVPCKMJVJLKETQ-UHFFFAOYSA-N
PubChem Compound ID
132417
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel alpha-1I subunit Target Info Inhibitor [525864]
Sodium channel Target Info Inhibitor [525864]
Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [525864]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Inhibitor [525864]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainmenthsa04728:Dopaminergic synapsehsa04010:MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-419037:NCAM1 interactionsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 545700Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004258)
Ref 525864J Med Chem. 2000 Sep 7;43(18):3372-6.Discovery of (2S)-1-(4-amino-2,3,5- trimethylphenoxy)-3-[4-[4-(4- fluorobenzyl)phenyl]-1-piperazinyl]-2-propanol dimethanesulfonate (SUN N8075): a dual Na(+) and Ca(2+) channel blocker with antioxidant activity.

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