Drug Information

Drug General Information
Drug ID
D0OW1R
Former ID
DIB007144
Drug Name
YM-43611
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Terminated [546030]
Company
Yamanouchi Pharmaceutical Co Ltd
Canonical SMILES
c1(C(=O)N[C@@H]2CN(Cc3ccccc3)CC2)c(cc(NC(=O)C2CC2)c(c1)<br />Cl)OC
CAS Number
CAS 169451-66-5
Target and Pathway
Target(s) D(3) dopamine receptor Target Info Modulator
D(4) dopamine receptor Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
GPCRs, Other
References
Ref 546030Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005975)

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