Drug Information

Drug General Information
Drug ID
D0OT5L
Former ID
DNC010062
Drug Name
7-propoxy-2H-chromen-2-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530514]
Formula
C12H12O3
Canonical SMILES
CCCOC1=CC2=C(C=C1)C=CC(=O)O2
InChI
1S/C12H12O3/c1-2-7-14-10-5-3-9-4-6-12(13)15-11(9)8-10/h3-6,8H,2,7H2,1H3
InChIKey
FCCCOTWGEKNZMI-UHFFFAOYSA-N
PubChem Compound ID
1631814
Target and Pathway
Target(s) Carbonic anhydrase XII Target Info Inhibitor [530514]
Carbonic anhydrase XIV Target Info Inhibitor [530514]
Carbonic anhydrase VI Target Info Inhibitor [530514]
Carbonic anhydrase IX Target Info Inhibitor [530514]
Carbonic anhydrase Target Info Inhibitor [530514]
KEGG Pathway Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolismhsa00910:Nitrogen metabolism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database HIF-1-alpha transcription factor network
Reactome Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1475029:Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBaseWP2770:Reversible Hydration of Carbon DioxideWP2770:Reversible Hydration of Carbon DioxideWP2877:Vitamin D Receptor Pathway
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.
Ref 530514J Med Chem. 2010 Jan 14;53(1):335-44.Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.

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