Drug Information

Drug General Information
Drug ID
D0OQ3L
Former ID
DNC001342
Drug Name
SL65.0472
Drug Type
Small molecular drug
Indication Cardiovascular disorder [ICD10:I00-I99] Discontinued in Phase 2 [547242]
Formula
C25H26FN5OS
Canonical SMILES
C=C1C=C(C2=C(N1CC(=O)N)C=C(C=C2)F)CCN3CCN(CC3)C4=NC=CC5<br />=C4C=CS5
InChI
1S/C25H26FN5OS/c1-17-14-18(20-3-2-19(26)15-22(20)31(17)16-24(27)32)5-8-29-9-11-30(12-10-29)25-21-6-13-33-23(21)4-7-28-25/h2-4,6-7,13-15H,1,5,8-12,16H2,(H2,27,32)
InChIKey
ZDPDWSUPGWKYLE-UHFFFAOYSA-N
PubChem Compound ID
56603793
PubChem Substance ID
134340538, 172080028
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Modulator
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547242Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014358)

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