Drug Information

Drug General Information
Drug ID
D0O9YQ
Former ID
DNC011232
Drug Name
N-n-hexyl-7-methoxytacrine hydrochloride
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531150]
Formula
C20H29ClN2O
Canonical SMILES
CCCCCCNC1=C2CCCCC2=NC3=C1C=C(C=C3)OC.Cl
InChI
1S/C20H28N2O.ClH/c1-3-4-5-8-13-21-20-16-9-6-7-10-18(16)22-19-12-11-15(23-2)14-17(19)20;/h11-12,14H,3-10,13H2,1-2H3,(H,21,22);1H
InChIKey
AVJCCLMBIUHWNE-UHFFFAOYSA-N
PubChem Compound ID
52941982
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [531150]
Cholinesterase Target Info Inhibitor [531150]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer PathwayWP229:Irinotecan Pathway
References
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
Ref 531150Bioorg Med Chem Lett. 2010 Oct 15;20(20):6093-5. Epub 2010 Aug 16.Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.

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