Drug Information

Drug General Information
Drug ID
D0O9UC
Former ID
DPR000158
Drug Name
Tak-220
Synonyms
AIDS228341; TAK220; TBR220; TBR-220; 1-acetyl-N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide
Drug Type
Small molecular drug
Indication HIV-1 infection [ICD9: 001-139, 042; ICD10:B20-B24] Phase 1 [542915], [548134]
Company
Takeda
Formula
C31H41ClN4O3
InChI
InChI=1S/C31H41ClN4O3/c1-22-4-9-28(21-29(22)32)36(31(39)27-12-18-35(19-13-27)23(2)37)15-3-14-34-16-10-25(11-17-34)20-24-5-7-26(8-6-24)30(33)38/h4-9,21,25,27H,3,10-20H2,1-2H3,(H2,33,38)
InChIKey
ASSJTMUEFHUKMJ-UHFFFAOYSA-N
PubChem Compound ID
5275766
PubChem Substance ID
7842083, 8614605, 15118413, 26683798, 39285330, 80704798, 85209511, 103486799, 104070043, 113840903, 135264154, 135651227, 137094365, 143364191, 198982063, 229087482, 248088162
Target and Pathway
Target(s) C-C chemokinereceptor type 5 Target Info Binder [536143]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 542915(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 800).
Ref 548134Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022281)
Ref 536143Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94.

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