Drug Information

Drug General Information
Drug ID
D0O9SG
Former ID
DNC012973
Drug Name
2-(4-chlorophenyl)-5-phenyl-4-isoxazolin-3-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528080]
Formula
C15H10ClNO2
Canonical SMILES
C1=CC=C(C=C1)C2=CC(=O)N(O2)C3=CC=C(C=C3)Cl
InChI
1S/C15H10ClNO2/c16-12-6-8-13(9-7-12)17-15(18)10-14(19-17)11-4-2-1-3-5-11/h1-10H
InChIKey
DWRJXWOCTFGHCE-UHFFFAOYSA-N
PubChem Compound ID
11543610
Target and Pathway
Target(s) Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [528080]
Gamma-aminobutyric acid receptor subunit beta-2 Target Info Inhibitor [528080]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Serotonergic synapse
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.
Ref 528080J Med Chem. 2006 Mar 23;49(6):1855-66.Synthesis, pharmacology, and structure-activity relationships of novel imidazolones and pyrrolones as modulators of GABAA receptors.

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