Drug Information

Drug General Information
Drug ID
D0O9MG
Former ID
DNC003524
Drug Name
L-655708
Synonyms
NCGC00025115-02
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467572]
Formula
C18H19N3O4
InChI
InChI=1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3
InChIKey
YKYOQIXTECBVBB-UHFFFAOYSA-N
PubChem Compound ID
4203080
PubChem Substance ID
6159941, 35488839, 56202987, 78586981, 85789021, 112752469, 162023057, 178101055, 178101178, 244705392
Target and Pathway
Target(s) Gamma-aminobutyric-acid receptor alpha-5 subunit Target Info Inhibitor [527005]
Gamma-aminobutyric acid receptor subunit alpha-1 Target Info Inhibitor [527005]
Gamma-aminobutyric-acid receptor alpha-3 subunit Target Info Inhibitor [527005]
Gamma-aminobutyric acid receptor Target Info Inhibitor [527005]
Gamma-aminobutyric-acid receptor alpha-2 subunit Target Info Inhibitor [527005]
Gamma-aminobutyric acid receptor subunit gamma-2 Target Info Inhibitor [527005]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addictionhsa04080:Neuroactive ligand-receptor interaction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activationR-HSA-975298:Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transportWP706:SIDS Susceptibility Pathways
Iron uptake and transportWP2754:Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467572(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4238).
Ref 527005J Med Chem. 2004 Mar 25;47(7):1807-22.3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

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