Drug Information

Drug General Information
Drug ID
D0O7NV
Former ID
DIB013171
Drug Name
DOV-51892
Synonyms
DOV-22047; GABA-A modulators, DOV
Indication Panic disorder [ICD9: 300.01, 300.21; ICD10:F41.0] Investigative [543814]
Company
DOV Pharmaceutical Inc
Canonical SMILES
C(=O)(c1c2nccc(n2nc1)c1cc(ncc1)Cl)c1ccccn1
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [543814]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).
Ref 543814(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 415).

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