Drug Information

Drug General Information
Drug ID
D0O7DB
Former ID
DIB007016
Drug Name
A-204176
Indication Stress urinary incontinence [ICD10:N39.3] Terminated [547179]
Company
Abbott Laboratories
Canonical SMILES
S(=O)(=O)(Nc1c2c(C(c3[nH]cnc3)CCC2)ccc1)C
CAS Number
CAS 258527-44-5
Target and Pathway
Target(s) Alpha-1A adrenergic receptor Target Info Agonist [526245]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
AMPK Signaling
References
Ref 547179Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013646)
Ref 526245Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function. Life Sci. 2001 Nov 30;70(2):181-97.

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