Drug Information

Drug General Information
Drug ID
D0O6NA
Former ID
DIB007879
Drug Name
JNJ-10229570
Synonyms
JNJ-10229570-AAA; MC5R antagonist (topical, acne), Johnson & Johnson; Melanocortin-5 receptor antagonist (topical, acne), Johnson & Johnson
Indication Acne vulgaris [ICD9: 706.1; ICD10:L70.0] Phase 2 [523417]
Company
Johnson & Johnson
Target and Pathway
Target(s) Melanocortin MC5 receptor Target Info Antagonist [531491]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 523417ClinicalTrials.gov (NCT01326780) A Study of a New Drug Treatment for Acne. U.S. National Institutes of Health.
Ref 531491A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63(1):23-32.

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