Drug Information

Drug General Information
Drug ID
D0O5ET
Former ID
DIB019511
Drug Name
compound 4b
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530316]
Formula
C27H28F2N4O3
InChI
InChI=1S/C27H28F2N4O3/c1-3-36-31-26(19-5-6-22(28)23(29)12-19)24-7-4-18(14-30-24)15-33-10-8-27(9-11-33)21-13-25(34)32(2)16-20(21)17-35-27/h4-7,12-14,16H,3,8-11,15,17H2,1-2H3/b31-26+
InChIKey
FPPIDMVDDSIXTQ-GKPLWNPISA-N
PubChem Compound ID
24890862
PubChem Substance ID
51083344, 57461006, 137906712, 230030014
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [530316]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530316Bioorg Med Chem Lett. 2009 Sep 15;19(18):5339-45. Epub 2009 Aug 6.Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.
Ref 530316Bioorg Med Chem Lett. 2009 Sep 15;19(18):5339-45. Epub 2009 Aug 6.Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.

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