Drug Information

Drug General Information
Drug ID
D0O4RB
Former ID
DIB016499
Drug Name
DdRNAi therapy rHIV7-shl-TAR-CCR5RZ, stem cells
Synonyms
BLT-HIV; Lentiviral vector delivered DNA-directed RNAi therapeutic (HIV infection), Benitec; RHIV7-shl-TAR-CCR5RZ; T-cell therapy (HIV infection), Benitec; Lentiviral vector delivered DNA-directed RNAi therapeutic (HIV-associated lymphoma), Benitec; DdRNAi therapy (rHIV7-shl-TAR-CCR5RZ, T-cells, HIV), Benitec; DdRNAi therapy (rHIV7-shl-TAR-CCR5RZ, stem cells, HIV/lymphoma), Benitec
Drug Type
RNAi therapeutics
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1/2 [550335]
Company
Benitec Ltd
Target and Pathway
Target(s) mRNA of CCR5 Target Info [544246]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
Endocytosis
Toxoplasmosis
Viral carcinogenesis
NetPath Pathway TSLP Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL12-mediated signaling events
Reactome Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
HIV Life Cycle
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 550335Clinical pipeline report, company report or official report of Benitec Ltd.
Ref 544246Progress on RNAi-based molecular medicines. Int J Nanomedicine. 2012; 7: 3971-3980.

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