Drug Information

Drug General Information
Drug ID
D0O4KI
Former ID
DNC008472
Drug Name
2-ethyl-4-(thiazol-2-yl)thieno[3,2-d]pyrimidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529419]
Formula
C11H9N3S2
Canonical SMILES
CCC1=NC2=C(C(=N1)C3=NC=CS3)SC=C2
InChI
1S/C11H9N3S2/c1-2-8-13-7-3-5-15-10(7)9(14-8)11-12-4-6-16-11/h3-6H,2H2,1H3
InChIKey
YNBYJWXOQPYWEM-UHFFFAOYSA-N
PubChem Compound ID
9834769
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [529419]
Adenosine A1 receptor Target Info Inhibitor [529419]
Adenosine A2b receptor Target Info Inhibitor [529419]
Adenosine A2a receptor Target Info Inhibitor [529419]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa04015:Rap1 signaling pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Alcoholismhsa04015:Rap1 signaling pathway
Parkinson's disease
Alcoholism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor networkhif2pathway:HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and AdenosinePW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-187024:NGF-independant TRKA activation
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR downstream signaling
GPCRs, Other
References
Ref 529419Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. Epub 2008 Mar 30.Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.
Ref 529419Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. Epub 2008 Mar 30.Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.

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