Drug Information

Drug General Information
Drug ID
D0O4IO
Former ID
DIB021263
Drug Name
ztz240
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542646]
Formula
C12H8ClFN2O
InChI
InChI=1S/C12H8ClFN2O/c13-11-6-5-10(7-15-11)16-12(17)8-1-3-9(14)4-2-8/h1-7H,(H,16,17)
InChIKey
URPKVELJRWKNQS-UHFFFAOYSA-N
PubChem Compound ID
3780776
PubChem Substance ID
5355977, 9969713, 12219452, 14774327, 25820757, 41631344, 53753202, 87350301, 87457387, 112185532, 125440713, 131564907, 138984601, 160687872, 165815419, 187563319, 196377600, 223366003, 231067715, 243151369, 252643828
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily KQT member 2 Target Info Activator [530996]
KEGG Pathway Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome Voltage gated Potassium channels
Interaction between L1 and Ankyrins
WikiPathways Potassium Channels
L1CAM interactions
References
Ref 542646(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7668).
Ref 530996Isoform-specific prolongation of Kv7 (KCNQ) potassium channel opening mediated by new molecular determinants for drug-channel interactions. J Biol Chem. 2010 Sep 3;285(36):28322-32.

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