Drug Information

Drug General Information
Drug ID
D0O3WY
Former ID
DNC000907
Drug Name
LY341495
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538855]
Formula
C12H13N5O6
InChI
InChI=1S/C12H13N5O6/c13-12(10(21)22,5-1-4(5)9(19)20)2-17-3-14-6-7(17)15-11(23)16-8(6)18/h3-5H,1-2,13H2,(H,19,20)(H,21,22)(H2,15,16,18,23)/t4-,5-,12+/m0/s1
InChIKey
GTVQXKHWYDSDNM-JRHNIRLTSA-N
CAS Number
CAS 181785-84-2
PubChem Compound ID
6324636
PubChem Substance ID
7979828, 11600139, 42973608, 57365646, 80842553, 114482012, 126671452, 134339090, 134340200, 135650552, 135651172, 163125169, 223663449, 243082378
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Antagonist [535639]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 538855(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1378).
Ref 535639Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats. Behav Neurosci. 2002 Dec;116(6):1075-83.

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