Drug Information

Drug General Information
Drug ID
D0O3PE
Former ID
DIB020818
Drug Name
RO 116 1148
Synonyms
RO 116-1148
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539641]
Formula
C19H28N2O3
InChI
InChI=1S/C19H28N2O3/c1-2-3-9-21-10-7-15(8-11-21)14-20-19(22)16-5-4-6-17-18(16)24-13-12-23-17/h4-6,15H,2-3,7-14H2,1H3,(H,20,22)
InChIKey
VBFBEYXWJLASJA-UHFFFAOYSA-N
PubChem Compound ID
44391713
PubChem Substance ID
90041758, 103446879, 135650937
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Antagonist [526322]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539641(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 252).
Ref 526322A 5-HT4 receptor transmembrane network implicated in the activity of inverse agonists but not agonists. J Biol Chem. 2002 Jul 12;277(28):25502-11. Epub 2002 Apr 25.

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