Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O1PM
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| Former ID |
DNC004003
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| Drug Name |
(4-Ethynyl-cyclohex-3-enyl)-dipropyl-amine
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| Synonyms |
4-ethynyl-N,N-dipropylcyclohex-3-enamine
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| Indication | Discovery agent | Investigative | [525701] | ||
| Canonical SMILES |
CCCN(CCC)C1CCC(=CC1)C#C
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| InChI |
1S/C14H23N/c1-4-11-15(12-5-2)14-9-7-13(6-3)8-10-14/h3,7,14H,4-5,8-12H2,1-2H3
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| InChIKey |
IOUKEEFTYOZOKJ-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | D(3) dopamine receptor | Target Info | Inhibitor | [529734] | |
| D(2) dopamine receptor | Target Info | Inhibitor | [525701] | ||
| D(4) dopamine receptor | Target Info | Inhibitor | [525701] | ||
| PANTHER Pathway | Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | ||||
| Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||||
| Dopamine receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| WikiPathways | Monoamine GPCRs | ||||
| GPCRs, Class A Rhodopsin-like | |||||
| GPCR ligand binding | |||||
| GPCR downstream signaling | |||||
| Nicotine Activity on Dopaminergic Neurons | |||||
| GPCRs, OtherWP666:Hypothetical Network for Drug Addiction | |||||
| Genes and (Common) Pathways Underlying Drug Addiction | |||||
| Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction | |||||
| GPCRs, Other | |||||
| References | |||||
| Ref 525701 | J Med Chem. 2000 Feb 24;43(4):756-62.Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype. | ||||
| Ref 529734 | J Med Chem. 2008 Nov 13;51(21):6829-38. Epub 2008 Oct 4.Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. | ||||
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