Drug Information

Drug General Information
Drug ID
D0O0LS
Former ID
DIB008673
Drug Name
RXDX 101
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1/2 [532994]
Company
Ignyta
Formula
C31H34F2N6O2
InChI
InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40)
InChIKey
HAYYBYPASCDWEQ-UHFFFAOYSA-N
PubChem Compound ID
25141092
PubChem Substance ID
56468453, 85003850, 103905026, 141279489, 223686891, 224447706, 229522507, 242521480, 246344423, 246919954, 249748717, 252164339, 252166502
Target and Pathway
Target(s) ROS1 Target Info Inhibitor [532994]
ALK tyrosine kinase receptor Target Info Inhibitor [532994]
BDNF/NT-3 growth factors receptor Target Info Inhibitor [543504]
Trk receptor Target Info Inhibitor [532994]
Neurotrophic tyrosine kinase receptor 1 Target Info Inhibitor [543043]
KEGG Pathway Non-small cell lung cancerhsa04010:MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholismhsa04010:MAPK signaling pathway
Endocytosis
Apoptosis
Inflammatory mediator regulation of TRP channels
Pathways in cancer
Transcriptional misregulation in cancer
Thyroid cancer
Central carbon metabolism in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signalingtrkrpathway:Neurotrophic factor-mediated Trk receptor signaling
Reactome NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activationR-HSA-170968:Frs2-mediated activation
ARMS-mediated activation
PI3K/AKT activation
WikiPathways Spinal Cord InjuryWP2848:Differentiation PathwayWP706:SIDS Susceptibility Pathways
BDNF signaling pathwayWP382:MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membraneWP382:MAPK Signaling Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 532994ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39.
Ref 532994ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39.
Ref 543043(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8290).
Ref 543504(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1818).

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