Drug Information

Drug General Information
Drug ID
D0O0EX
Former ID
DIB008534
Drug Name
SAR-110894
Synonyms
SAR-110894D
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [523311]
Company
Sanofi
Target and Pathway
Target(s) Histamine H3 receptor Target Info Antagonist [531888]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Histamine receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 523311ClinicalTrials.gov (NCT01266525) Effect of Different Doses of SAR110894D on Cognition in Patients With Mild to Moderate Alzheimer's Disease on Donepezil. U.S. National Institutes of Health.
Ref 531888SAR110894, a potent histamine H??receptor antagonist, displays procognitive effects in rodents. Pharmacol Biochem Behav. 2012 Aug;102(2):203-14.

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