Drug Information

Drug General Information
Drug ID
D0NU6Y
Former ID
DIB006221
Drug Name
192C86
Synonyms
BW-192C86
Drug Type
Small molecular drug
Indication Thrombosis [ICD9: 437.6, 453, 671.5, 671.9; ICD10:I80-I82] Phase 1 [526857]
Company
Burroughs Wellcome Inc
Formula
C20H33N3O4S
Canonical SMILES
N1(C(=O)N(C2C1CC(C2)SCCCC(=O)O)CC)/N=C/C(C1CCCCC1)O
CAS Number
CAS 139147-26-5
PubChem Compound ID
9576901
Target and Pathway
Target(s) Prostaglandin D2 receptor Target Info Modulator [544117]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 526857The effect of a prostaglandin DP-receptor partial agonist (192C86) on platelet aggregation and the cardiovascular system in healthy volunteers. Br J Clin Pharmacol. 1992 Oct;34(4):344-51.
Ref 544117Prostanoid receptor antagonists: development strategies and therapeutic applications. Br J Pharmacol. 2009 September; 158(1): 104-145.

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