Drug Information

Drug General Information
Drug ID
D0N7UE
Former ID
DNC003845
Drug Name
Imidazolidin-2-ylidene-quinoxalin-6-yl-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551280]
Formula
C11H11N5
Canonical SMILES
C1CN=C(N1)NC2=CC3=NC=CN=C3C=C2
InChI
1S/C11H11N5/c1-2-9-10(13-4-3-12-9)7-8(1)16-11-14-5-6-15-11/h1-4,7H,5-6H2,(H2,14,15,16)
InChIKey
PVKUNRLEOHFACD-UHFFFAOYSA-N
PubChem Compound ID
10198248
Target and Pathway
Target(s) Alpha-1B adrenergic receptor Target Info Inhibitor [551280]
Alpha-1A adrenergic receptor Target Info Inhibitor [551280]
Alpha-1D adrenergic receptor Target Info Inhibitor [551280]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretionhsa04020:Calcium signaling pathway
AMPK signaling pathway
Salivary secretion
NetPath Pathway IL2 Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling eventsR-HSA-390696:Adrenoceptors
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Vitamin D Receptor Pathway
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
AMPK SignalingWP58:Monoamine GPCRs
Endothelin Pathways
GPCRs, Other
References
Ref 551280Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).
Ref 551280Analogs of UK 14,304: Structural features responsible for alpha2 adrenoceptor activity, Bioorg. Med. Chem. Lett. 5(15):1745-1750 (1995).

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