Drug Information

Drug General Information
Drug ID
D0N7MQ
Former ID
DIB013968
Drug Name
Small molecule 33
Synonyms
IDDBCP233389
Indication Congestive heart failure [ICD9: 428; ICD10:I50] Investigative [543921]
Company
Evotec AG
Canonical SMILES
c1(ccc(cc1)c1ccc(cc1)C(=O)N1CCC(CC1)Cc1[nH]ccn1)F
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [543921]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 543921(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7).
Ref 543921(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 7).

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