Drug Information

Drug General Information
Drug ID
D0N4PW
Former ID
DIB008148
Drug Name
iOWH032
Synonyms
CFTR inhibitors (diarrhea); IOWH-032; CFTR inhibitors (diarrhea), BioFocus
Indication Diarrhea [ICD9: 787.91; ICD10:A09, K59.1] Phase 2 [524714]
Company
The Institute for OneWorld Health
Canonical SMILES
o1nc(nc1C(=O)NCc1ccc(cc1)Oc1ccccc1)c1cc(c(c(c1)Br)O)Br
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Inhibitor [531605]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 524714ClinicalTrials.gov (NCT02111304) Efficacy of iOWH032 in Dehydrating Cholera. U.S. National Institutes of Health.
Ref 531605Developing novel antisecretory drugs to treat infectious diarrhea. Future Med Chem. 2011 Aug;3(10):1317-25.

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