Drug Information

Drug General Information
Drug ID
D0N4FJ
Former ID
DIB001129
Drug Name
CFTR inhibitors
Synonyms
CFTR inhibitors (diarrhea); CFTR inhibitors (diarrhea), IOWH/Novartis; CFTR inhibitors (diarrhea), The Institute for OneWorld Health/Novartis
Indication Diarrhea [ICD9: 787.91; ICD10:A09, K59.1] Investigative [552165]
Company
The Institute for OneWorld Health
Canonical SMILES
c1(c(cc(cc1Br)c1nnc(nc1)OCc1ccc(cc1)Cl)Br)O
Target and Pathway
Target(s) cystic fibrosis transmembrane conductance regulator Target Info Inhibitor [543927]
KEGG Pathway ABC transporters
cAMP signaling pathway
AMPK signaling pathway
Gastric acid secretion
Pancreatic secretion
Bile secretion
Vibrio cholerae infection
Reactome ABC-family proteins mediated transport
WikiPathways ABC-family proteins mediated transport
References
Ref 552165US patent application no. 2004235879, USE OF CFTR INHIBITORS FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED DIARRHEA.
Ref 543927(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 707).

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