Drug Information

Drug General Information
Drug ID
D0N2TF
Former ID
DIB020792
Drug Name
R214127
Synonyms
R 214127; R-214127
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541482]
Formula
C20H17NO2
InChI
InChI=1S/C20H17NO2/c22-19(11-14-5-2-1-3-6-14)15-8-9-18-17(12-15)13-16-7-4-10-23-20(16)21-18/h1-3,5-6,8-9,12-13H,4,7,10-11H2
InChIKey
HXUSRWUBSYSWII-UHFFFAOYSA-N
PubChem Compound ID
10470232
PubChem Substance ID
22800623, 40597836, 48179660, 48253893, 77933775, 85228445, 103439245, 104049589, 135651195, 139344264, 162527069, 178102954, 226959953, 247424493
Target and Pathway
Target(s) Metabotropicglutamate receptor 1 Target Info Modulator (allosteric modulator) [526599]
KEGG Pathway Calcium signaling pathway
FoxO signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Long-term depression
Estrogen signaling pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 541482(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6336).
Ref 526599[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists. Mol Pharmacol. 2003 May;63(5):1082-93.

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