Drug Information

Drug General Information
Drug ID
D0MU4A
Former ID
DIB020976
Drug Name
spiroxatrine
Synonyms
spiroxamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540759]
Formula
C22H25N3O3
InChI
InChI=1S/C22H25N3O3/c26-21-22(25(16-23-21)17-6-2-1-3-7-17)10-12-24(13-11-22)14-18-15-27-19-8-4-5-9-20(19)28-18/h1-9,18H,10-16H2,(H,23,26)
InChIKey
JVGBTTIJPBFLTE-UHFFFAOYSA-N
PubChem Compound ID
5268
PubChem Substance ID
239745, 511095, 5614464, 8153239, 11426887, 14902387, 17405698, 24278126, 26751807, 26751808, 29224323, 48035367, 48259474, 48334741, 50064107, 50104500, 50104501, 53778248, 57322687, 76693065, 85089532, 85209933, 85231214, 85788304, 90341505, 91746427, 92303168, 92308813, 103249514, 103931109, 104171234, 104308748, 121361869, 124750267, 124881358, 124881359, 124881360, 126408104, 128332426, 135028248, 135651066, 135697853, 137010278, 137263948, 138809382, 142936465, 144203811, 162022505, 162090868, 163138086
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Agonist [534714]
5-hydroxytryptamine 2B receptor Target Info Antagonist [534554]
Alpha-2B adrenergic receptor Target Info Antagonist [533843]
Alpha-2C adrenergic receptor Target Info Antagonist [526102]
Alpha-1B adrenergic receptor Target Info Antagonist [526102]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
cGMP-PKG signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (z) signalling events
Surfactant metabolismR-HSA-390696:Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signalingWP58:Monoamine GPCRs
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
Calcium Regulation in the Cardiac Cell
Vitamin D Receptor Pathway
GPCR downstream signaling
AMPK Signaling
References
Ref 540759(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 53).
Ref 526102Affinity of serotonin receptor antagonists and agonists to recombinant and native alpha1-adrenoceptor subtypes. Jpn J Pharmacol. 2001 Jun;86(2):189-95.
Ref 533843The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors. J Pharmacol Exp Ther. 1994 Dec;271(3):1558-65.
Ref 534554[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24.
Ref 534714Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56.

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