Drug Information

Drug General Information
Drug ID
D0MT0A
Former ID
DCL000080
Drug Name
CCX915
Drug Type
Small molecular drug
Indication Multiple scierosis [ICD9: 340; ICD10:G35] Discontinued in Phase 1 [549358]
Company
ChemoCentryx
Formula
C17H16ClNO4
Canonical SMILES
COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)C(=O)O
InChI
1S/C17H16ClNO4/c1-23-15-7-6-13(18)10-14(15)16(20)19-9-8-11-2-4-12(5-3-11)17(21)22/h2-7,10H,8-9H2,1H3,(H,19,20)(H,21,22)
InChIKey
SWLAMJPTOQZTAE-UHFFFAOYSA-N
PubChem Compound ID
41214
PubChem Substance ID
7979884, 8176982, 12015467, 14924472, 34706879, 49886456, 53619121, 57312524, 93041310, 103394414, 104336385, 117460715, 126416115, 129298599, 134224981, 134338778, 134340208, 135003046, 137231470, 142710612, 179150609, 198951658, 226423603, 241095530, 249757752, 251960696
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [550191]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 549358Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035649)
Ref 550191Marketed and experimental medicines for the treatment of multiple sclerosis. The Association of the British Pharmaceutical Industry. 2009.

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