Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0M9IC
|
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| Former ID |
DNC008643
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| Drug Name |
CONESSINE
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [529537] | ||
| Formula |
C24H40N2
|
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| Canonical SMILES |
CC1C2CCC3C2(CCC4C3CC=C5C4(CCC(C5)N(C)C)C)CN1C
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| InChI |
1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
|
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| InChIKey |
GPLGAQQQNWMVMM-MYAJQUOBSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histamine H3 receptor | Target Info | Inhibitor | [530254] | |
| Trypanothione reductase | Target Info | Inhibitor | [529537] | ||
| Alpha-2C adrenergic receptor | Target Info | Inhibitor | [529632] | ||
| References | |||||
| Ref 529537 | Bioorg Med Chem. 2008 Jul 15;16(14):6689-95. Epub 2008 Jun 2.The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. | ||||
| Ref 529632 | J Med Chem. 2008 Sep 11;51(17):5423-30. Epub 2008 Aug 7.The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. | ||||
| Ref 530254 | J Med Chem. 2009 Aug 13;52(15):4640-9.Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships. | ||||
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