Drug Information

Drug General Information
Drug ID
D0M8CJ
Former ID
DIB020859
Drug Name
RS-102895
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542740]
Formula
C21H21F3N2O2
InChI
InChI=1S/C21H21F3N2O2/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20/h1-8H,9-14H2,(H,25,27)
InChIKey
HIDWEYPGMLIQSN-UHFFFAOYSA-N
PubChem Compound ID
10000456
PubChem Substance ID
14980159, 22435387, 24724588, 29215126, 44092572, 57373982, 76996781, 135650935, 138230842, 172914685, 177748546, 179694567, 223550153, 235319583, 242386684, 244256225
Target and Pathway
Target(s) C-C chemokine receptor type 2 Target Info Antagonist [525750]
KEGG Pathway Cytokine-cytokine receptor interaction
Chemokine signaling pathway
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Leptin Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Reactome Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Defensins
Spinal Cord Injury
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 542740(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 779).
Ref 525750J Biol Chem. 2000 Aug 18;275(33):25562-71.Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helicalbundle.

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