Drug Information

Drug General Information
Drug ID
D0M7CB
Former ID
DIB014984
Drug Name
MK-0873
Synonyms
MK-0873 (dermatological, psoriasis); MK-0873 (dermatological, psoriasis), Merck & Co
Drug Type
Small molecular drug
Indication Psoriasis [ICD9: 696; ICD10:L40] Phase 2 [521664]
Company
Merck & Co Inc
Formula
C25H18N4O3
Canonical SMILES
c1cc2c(n(cc(c2=O)C(=O)NC2CC2)c2cccc(c2)C#Cc2c[n+](ccc2)<br />[O-])nc1
PubChem Compound ID
9919680
Target and Pathway
Target(s) CAMP-specific 3',5'-cyclic phosphodiesterase 4A Target Info Inhibitor [529356]
CAMP-specific 3',5'-cyclic phosphodiesterase 4B Target Info Inhibitor [529356]
Type IV phosphodiesterase Target Info Inhibitor [529356]
KEGG Pathway Purine metabolism
cAMP signaling pathway
Morphine addictionhsa00230:Purine metabolism
Morphine addiction
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
PathWhiz Pathway Purine Metabolism
Reactome DARPP-32 events
G alpha (s) signalling eventsR-HSA-180024:DARPP-32 events
G alpha (s) signalling events
WikiPathways G Protein Signaling PathwaysWP35:G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
Nuclear Receptors Meta-Pathway
Opioid SignallingWP35:G Protein Signaling Pathways
TSH signaling pathway
References
Ref 521664ClinicalTrials.gov (NCT00132730) An Investigational Drug Study In Patients With COPD (Chronic Obstructive Pulmonary Disease) (MK-0873-005). U.S. National Institutes of Health.
Ref 529356MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers. Pulm Pharmacol Ther. 2008;21(3):573-7.

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