Drug Information

Drug General Information
Drug ID
D0M6YW
Former ID
DIB003027
Drug Name
GYKI-12743
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 1 [545079]
Company
Gedeon Richter Ltd
Formula
C16H20ClN3O3
Canonical SMILES
n1(c(=O)cccn1)CCCNCC1Oc2c(OC1)cccc2.Cl
CAS Number
CAS 110714-10-8
PubChem Compound ID
163825
Target and Pathway
Target(s) Alpha-2C adrenergic receptor Target Info Modulator [528315]
KEGG Pathway cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Alpha adrenergic receptor signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (i) signalling events
G alpha (z) signalling events
Surfactant metabolism
WikiPathways Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Platelet Aggregation (Plug Formation)
Integration of energy metabolism
GPCR ligand binding
GPCR downstream signaling
References
Ref 545079Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002059)
Ref 528315GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist. Acta Physiol Hung. 1991;77(3-4):257-67.

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