Drug Information

Drug General Information
Drug ID
D0M6BA
Former ID
DNCL002406
Drug Name
AR-67
Drug Type
Small molecular drug
Indication Glioblastoma multiforme; Myelodysplastic syndrome [ICD9: 191, 238.7; ICD10:C71, D46] Phase 2 [523046]
Company
Arno Therapeutics
Formula
C26H30N2O5Si
PubChem Compound ID
6712744
Target and Pathway
Target(s) Toposisomerase-1 Target Info Inhibitor [532769]
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway DNA replication
Pathway Interaction Database Caspase Cascade in Apoptosis
WikiPathways Integrated Pancreatic Cancer Pathway
References
Ref 523046ClinicalTrials.gov (NCT01124539) Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma. U.S. National Institutes of Health.
Ref 532769Protracted dosing of the lipophilic camptothecin analogue AR-67 in non-small cell lung cancer xenografts and humans. Cancer Chemother Pharmacol. 2014 Jul;74(1):45-54.

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